Free access to the latest research
Welcome to the Obstetrics Resource Centre, with free access to the latest research in the field.
All content is independently selected by the Editors, Professor James O. Drife from Leeds, UK, and Professor Jim Thornton from Nottingham. The Obstetrics Resource Centre provides you with original articles, reviews, selected must-reads, lectures and a congress planner.
From the other journals
Editor’s comment: Prof. Jim Thornton:Ten different Caesarean section techniques are equally safe
Three year follow up of the CORONIS factorial trial comparing single with two layer closure, catgut with polygalactin, exteriorisation or not, peritoneal closure or not and blunt versus sharp abdominal entry, has shown no important differences in any of the predefined outcomes.
Caesarean section surgical techniques: 3 year follow-up of the CORONIS fractional, factorial, unmasked, randomised controlled trial
The CORONIS collaborative groupThe CORONIS collaborative group (2016) Caesarean section surgical techniques: 3 year follow-up of the CORONIS fractional, factorial, unmasked, randomised controlled trial. Lancet Jul 02, 2016, 388; 62-72.
Editor’s comment: Prof. Jim Thornton: Induction of labour for suspected macrosomia
Induction of labour for suspected fetal macrosomia reduces birthweight, fractures and shoulder dystocia. It does not appear to alter the rate of caesarean or instrumental delivery. The trials were too small to estimate the effect of induction on brachial plexus injury.
Boulvain M et al.Cochrane Database Syst Rev. 2016 May 22;(5):CD000938. doi: 10.1002/14651858.CD000938.pub2
Selected AJOG Papers
Editor’s comment: Prof. Yves Ville: Non-invasive whole fetal genome sequencing : Putting the cart before the horse ?
(Editor's comment relates to the AJOG article below)
The development of next-generation sequencing (NGS) technologies (ie, new high-throughput and massively parallel DNA sequencing technologies) has substantially reduced both the cost and the time required to sequence an entire human genome. Its application to the human fetus has become a reality that is close to clinical implementation. (Lefkowitz R. et al) It is therefore both critical and urgent to be prepared for a shift in paradigm in prenatal screening and diagnosis.
Clinical validation of a noninvasive prenatal test for genomewide detection of fetal copy number variants
Roy B. Lefkowitz PhD, John A. Tynan PhD, Tong Liu PhD, Yijin Wu PhD, Amin R. Mazloom PhD, Eyad Almasri MS, Grant Hogg MS, Vach Angkachatchai PhD, Chen Zhao PhD, Daniel S. Grosu MD, Graham McLennan MS, Mathias Ehrich MD
American Journal of Obstetrics and Gynecology, Volume 215, Issue 2, August 2016, Pages 227.e1 - 227.e16
Editor’s comment: Prof. Dan Farine: Disclosure of possible conflicts and other pitfalls waiting those who publish
(Editor's comment relates to the AJOG article below)
In this interesting paper the major finding is that 68% of physicians submitting a paper to the Society of Gynecological Surgery (SGS) did not properly disclose their full relationship to industry. Interestingly, the way that the under-reporting was found was based on earlier disclosure of these physicians of such a relationship.
Publishing is a way to achieve recognition as an expert and academic promotion. Publications are the major way to disseminate new information and improve medical practice. Individuals may feel pressure to publish for these reasons. The editors and readers want to see the best information published and they want to be sure that biases are optimally eliminated or at least disclosed...
Jennifer C. Thompson MD, Katherine A. Volpe MD, Lindsay K. Bridgewater MD, Fares Qeadan PhD, Gena C. Dunivan MD, Yuko M. Komesu MD, Sara B. Cichowski MD, Peter C. Jeppson MD, Rebecca G. Rogers MD
American Journal of Obstetrics and Gynecology, In Press, Uncorrected Proof, Available online 16 June 2016, Available online 16 June 2016
Editor’s comment: Prof. Dan Farine: Acidemia with Normal pH:
(Editor's comment relates to the AJOG article below)
This interesting study looks retrospectively at the rare occurrence of acidemia and/or low base access in babies with normal Apgar scores. The “common sense approach” has been to assume that the test is erroneous as the baby was doing well and ignore it. In Medico-Legal conferences the rationale for pushing for universal cord pH testing has been that it may identify the group of interest for asphyxia (low pH and Apgar scores). According to this approach it was even more interesting to identify the neonates with a normal pH and base excess. These babies may have been exposed to a hostile intra-uterine environment based on history and/or abnormal fetal heart rates and possibly to less than optimal care. However, since they were not acidotic they would not go on to develop cerebral palsy based on the McLennan dogma that was adopted by the major obstetrical societies (FIGO, ACOG, UK guidelines Australian-NZ ones etc.)...
Bethany A. Sabol MD, Aaron B. Caughey MD, PhD
American Journal of Obstetrics and Gynecology, In Press, Uncorrected Proof, Available online 31 May 2016, Available online 31 May 2016
Editor’s comment: Prof. Yves Ville: To know the chance, a chance to know.
(Editor’s comment relates to the 3 AJOG articles below…)
Advanced screening for fetal aneuploidies using fetal DNA in maternal blood represents a major technical breakthrough that is still struggling to find a pragmatic place within the screening algorithms in most countries, after 4 years of clinical use. The wide and sometimes wild dissemination of the test stresses the critical need for the prescribers of the test to understand the difficulties of its interpretation.
Chromosomal abnormalities not currently detected by cell-free fetal DNA: a retrospective analysis at a single center
Hagit Shani MD, Tamar Goldwaser MD, Jennifer Keating MS, Susan Klugman MD
American Journal of Obstetrics and Gynecology, Volume 214, Issue 6, June 2016, Pages 729.e1 - 729.e11
Mary E. Norton MD, Rebecca J. Baer MPH, Ronald J. Wapner MD, Miriam Kuppermann PhD, Laura L. Jelliffe-Pawlowski PhD, Robert J. Currier PhD
American Journal of Obstetrics and Gynecology, Volume 214, Issue 6, June 2016, Pages 727.e1 - 727.e6
Editor’s comment: Prof. Yves Ville: An unsuspected enemy is doubly dangerous (L. Frank Baum)
(Editor’s comment relates to the 3 AJOG articles below: Aubry et al, Khalifeh et al & Saade et al)
Over a third of infant deaths arise from complications related to preterm births, making prematurity the most frequent cause of infant mortality. Health complications are also a lifelong burden of survivors including mental retardation, cerebral palsy, learning and behavioral problems, respiratory problems, vision and hearing loss, but also diabetes, high blood pressure, and heart disease. This inventory has become a classic lament of perinatologists facing the implacable consequences of prematurity.
Trends in prematurity have been either on the rise (1990-2006) or flattening (2006-2013) with medically indicated « late » prematurity as the main adjustment variable. However around 1/25 pregnancies still face unexpected delivery before 33 weeks’ and roughly half of them are primigravidas without anticipated risk factors...
High-risk obstetrics: Perinatal outcome in relation to a broadened approach to obstetric care for patients at special risk
Richard H. Aubry, MD, Robert E. L. Nesbitt Jr., MDAmerican Journal of Obstetrics and Gynecology, Volume 105, Issue 2, 15 September 1969, Pages 241–247
George R. Saade MD, Kim A. Boggess MD, Scott A. Sullivan MD, Glenn R. Markenson MD, Jay D. Iams MD, Dean V. Coonrod MD, Leonardo M. Pereira MD, M. Sean Esplin MD, Larry M. Cousins MD, Garrett K. Lam MD, Matthew K. Hoffman MD, Robert D. Severinsen BS, Trina Pugmire BS, Jeff S. Flick PhD, Angela C. Fox MS, Amir J. Lueth MPH, Sharon R. Rust BS, Emanuele Mazzola PhD, ChienTing Hsu MS, Max T. Dufford BS, Chad L. Bradford MS, Ilia E. Ichetovkin PhD, Tracey C. Fleischer PhD, Ashoka D. Polpitiya DSc, Gregory C. Critchfield MD, Paul E. Kearney PhD, J. Jay Boniface PhD, Durlin E. Hickok MD
Editor’s comment: Prof. Yves Ville: Is the due date becoming overdue ?
(Editor’s comment relates to the 3 AJOG articles below: Gibson et al, Melamed et al & Masoudian et al)
In vitro fertilization using egg donation (ED) is being used increasingly for women requiring assisted reproduction techniques (ART) with a delivery rate per transfer of around 40%. Initially designed to overcome infertility in young women with hypergonadotropic hypogonadism, this technique is now also increasingly used to achieve pregnancy in older women.
Multiple studies have documented that ED pregnancies are associated with a higher incidence of pregnancy-induced hypertension and placental dysfunction, including small for gestational age, and preterm delivery. However, multiple gestations, advanced age, and underlying polycystic ovary syndrome are constant confounding factors for all studies examining the association between assisted reproductive techniques (ARTs) and hypertensive disorders in pregnancy...
A risk of waiting: the weekly incidence of hypertensive disorders and associated maternal and neonatal morbidity in low-risk term pregnancies
Kelly S. Gibson MD, Thaddeus P. Waters MD, Jennifer L. Bailit MD, MPH
American Journal of Obstetrics and Gynecology, Volume 214, Issue 3, March 2016, Pages 389.e1 - 389.e12
Induction of labor before 40 weeks is associated with lower rate of cesarean delivery in women with gestational diabetes mellitus
Nir Melamed MD, Joel G. Ray MD, Michael Geary MD, Daniel Bedard MSc, Cathy Yang MSc, Ann Sprague PhD, Beth Murray-Davis PhD, Jon Barrett MD, Howard Berger MD
American Journal of Obstetrics and Gynecology, Volume 214, Issue 3, March 2016, Pages 364.e1 - 364.e8
Oocyte donation pregnancies and the risk of preeclampsia or gestational hypertension: a systematic review and metaanalysis
Pourya Masoudian BHSc, Ahmed Nasr MD, MSc, Joseph de Nanassy MD, Karen Fung-Kee-Fung MD, MHPE, Shannon A. Bainbridge PhD, Dina El Demellawy MD, PhD
American Journal of Obstetrics and Gynecology, Volume 214, Issue 3, March 2016, Pages 328 - 339
About the Editors
- Jim Thornton is Professor of Obstetrics and Gynaecology, at Nottingham University, and deputy director of the Nottingham Clinical Trials Unit...
- Dr Dan Farine is a Professor of Obstetrics & Gynaecology at the University of Toronto. He is cross appointed to...
- Yves Ville is a Professor of Obstetrics and Gynecology at Paris University since 1998 and is head of Obstetrics and...
- T ak Yeung LEUNG is the Chairman of the Department of Obstetrics and Gynaecology of The Chinese University of Hong...
- James Drife is Emeritus Professor of Obstetrics and Gynaecology at the University of Leeds, UK. He has written widely on...