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From the other Journals

The articles in this section have been identified by the editor of the resource centre, Jim Thornton, Professor of Obstetrics and Gynecology at Nottingham University, UK, as key publications in the area of Obstetrics Gynecology.

All key publications are available online with external links plus editorial commentaries and titles written specifically for the EJOG resource centre by Prof. Jim Thornton.

  • Amniotic lactate and oxytocin augmentation

    Wiberg-Itzel E et al.

    Lactate in Amniotic Fluid: Predictor of Labor Outcome in Oxytocin-Augmented Primiparas' Deliveries. PLoS One. 2016 Oct 26;11(10):e0161546. doi: 10.1371/journal.pone.0161546.
  • Editor's comment: Prof. Jim Thornton: Inverse correlation between rates of operative vaginal delivery and Caesarean

    A large Italian registry study has shown, perhaps unsurprisingly, a significant inverse correlation between rates of overall Caesarean birth and operative vaginal delivery rates.  The authors note the rising rate of second stage Caesareans, which are often very morbid for both mother and baby, and advocate a careful change in obstetric culture to encourage vaginal instrumental delivery in delayed second stage of labour. 

    Cesarean delivery rates and obstetric culture - an Italian register-based study

    Plevani et al.

    Acta Obstet Gynecol Scand. 2016 Nov 21. doi: 10.1111/aogs.13063.
  • Editor's comment: Prof. Jim Thornton: Induction and Autism; reassurance from Sweden
    Some previous research had suggested an association between labour induction and autism disorders. However in this large study from Sweden, comparison with siblings whose births were discordant with respect to induction, thus accounting for shared environmental and genetic factors, induction was not associated with autism in the child (HR, 0.99; 95% CI, 0.88-1.1).
    Oberg AS et al. Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders. JAMA Pediatr. 2016 Sep

    Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders.

    6;170(9):e160965. doi: 10.1001/jamapediatrics.2016.0965. Epub 2016 Sep 6.
  • Editor's comment: Prof. Jim Thornton: Core outcomes for preterm birth
    Core outcomes which should be reported in trials and other evaluations of interventions to prevent preterm birth have been published. This is part of the CROWN initiative Core outcome in Women's and Newborn health. There are four maternal outcomes (mortality; infection or inflammation; prelabour rupture of membranes; harm from intervention) and nine baby ones (gestational age at birth; mortality; birthweight; early neurodevelopmental morbidity; late neurodevelopmental morbidity; gastrointestinal morbidity; Infection; respiratory morbidity; and harm from intervention.

    A core outcome set for evaluation of interventions to prevent preterm birth: summary for CROWN

    Van 't Hooft J (2016) A core outcome set for evaluation of interventions to prevent preterm birth: summary for CROWN. BJOG 2016 Sep;123 Suppl 3:107. doi: 10.1111/1471-0528.14364.
  • Editor’s comment: Prof. Jim Thornton:Ten different Caesarean section techniques are equally safe
    Three year follow up of the CORONIS factorial trial comparing single with two layer closure, catgut with polygalactin, exteriorisation or not, peritoneal closure or not and blunt versus sharp abdominal entry, has shown no important differences in any of the predefined outcomes. 

    Caesarean section surgical techniques: 3 year follow-up of the CORONIS fractional, factorial, unmasked, randomised controlled trial

    The CORONIS collaborative group

    The CORONIS collaborative group (2016) Caesarean section surgical techniques: 3 year follow-up of the CORONIS fractional, factorial, unmasked, randomised controlled trial. Lancet Jul 02, 2016, 388; 62-72.
  • Editor’s comment: Prof. Jim Thornton: Induction of labour for suspected macrosomia
    Induction of labour for suspected fetal macrosomia reduces birthweight, fractures and shoulder dystocia. It does not appear to alter the rate of caesarean or instrumental delivery. The trials were too small to estimate the effect of induction on brachial plexus injury.

    Induction of labour at or near term for suspected fetal macrosomia

    Boulvain M et al.

    Cochrane Database Syst Rev. 2016 May 22;(5):CD000938. doi: 10.1002/14651858.CD000938.pub2
  • Editor’s comment: Prof. Jim Thornton: Lifestyle programmes for overweight infertile women
    This randomised trial comparing a six month lifestyle intervention programme preceding infertility treatment, with prompt infertility treatment, for women with a BMI of greater than 29, showed no effect on birth rates over two years.

    Randomized Trial of a Lifestyle Program in Obese Infertile Women

    Mutsaerts, MAQ et al.

    N Engl J Med 2016; 374:1942-1953
  • Editor’s comment: Prof. Jim Thornton: Worldwide abortion trends
    Abortion rates have fallen significantly, albeit from fairly high levels, in the developed world since 1990. In the developing world levels were lower in 1990, but have hardly changed.

    Abortion incidence between 1990 and 2014: global, regional, and subregional levels and trends

    Sedgh G, et al.

    Lancet. 11 May 2106. Online first.
  • Editor’s comment: Prof. Jim Thornton: Network meta-analysis of methods to induce labour
    611 studies comparing 31 active interventions were analysed. Intravenous oxytocin with amniotomy and vaginal misoprostol (≥50 μg) were most likely to achieve vaginal delivery within 24 hours. Titrated low-dose oral misoprostol achieved the lowest odds of caesarean section. Buccal/sublingual and titrated (low-dose) misoprostol showed the highest probability of being cost-effective. However, the quality of many of the primary studies was poor and there was considerable uncertainty in all the estimates.

    Methods to induce labour: a systematic review, network meta-analysis and cost-effectiveness analysis

    Z Alfirevic, et al.

    BJOG 22 March 2016 Online. DOI: 10.1111/1471-0528.13981
  • Editor’s comment: Prof. Jim Thornton: Treatment of post-partum haemorrhage in France
    Rates of maternal mortality from haemorrhage, and the use of invasive therapies to treat post-partum haemorrhage in France, are both considerably higher than other countries in Western Europe. This suggests that primary management of post-partum haemorrhage may be suboptimal.

    Invasive therapies for primary postpartum haemorrhage: a population-based study in France

    Kayem G, Dupont C, Bouvier-Colle MH, Rudigoz RC, Deneux-Tharaux C

    BJOG 2016;123:598–605.



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Commentaries by Editor Prof. Jim Thornton