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Antenatal Betamethasone for Women at Risk for Late Preterm Delivery
Gyamfi‑Bannerman C, et al.
Editor's comment: Prof. Jim Thornton: Steroids for lung maturity at late preterm birth
There is already strong evidence for benefit from prenatal steroids administered for preterm labour before 34 weeks. The evidence is less clear for labour between 34 and 37 weeks. This large well-conducted trial has now clearly shown benefit in terms of reduced adverse neonatal composite outcome (CPAP, supplemental O2, ECMO, mechanical ventilation or death) among foetuses of women in labour between 34 and 37 weeks. Relative risk of primary neonatal compiste 0.8; 95% CI 0.66 - 0.97. However there was a marked increase in neonatal hypoglycaemia in the steroid group, RR 1.60; 95% CI, 1.37 - 1.87.