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The ED90 of prophylactic oxytocin infusion after delivery of the placenta during cesarean delivery in laboring compared with nonlaboring women: an up-down sequential allocation dose-response study
Editor's comment: Prof. Jim Thornton: Higher doses of oxytocin needed to prevent bleeding after Caesarean in women in labour
It has long been known that rates of post-partum haemorrhage are higher after prolonged labour whether delivery is vaginal or by Caesarean. This study confirms one possible cause. Among women delivered by Caesarean section a higher dose of oxytocin by infusion is required to achieve satisfactory uterine contractility and stop bleeding in women who have been in labour.