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A Randomized Trial of a Cervical Pessary to Prevent Preterm Singleton Birth

Nicolaides KH, Syngelaki A, Poon LC, Picciarelli G, Tul N, Zamprakou A, Skyfta E, Parra-Cordero M, Palma-Dias R, Rodriguez Calvo J

New England Journal of Medicine, 2016 Mar 17;374(11):1044-52. doi: 10.1056/NEJMoa1511014

Editor’s comment: Prof. Jim Thornton: Arabin cerclage pessary does not reduce preterm birth in singletons
A large trial led by Kypros Nicolaides, and published in the New England Journal of Medicine, has shown that among singleton pregnancies where the cervical length has been measured to be reduced on scan, the use of the Arabin cerclage pessary does not reduce the rate of delivery before 34 weeks. No other substantive adverse outcomes were reduced either.   


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Commentaries by Editor Prof. Jim Thornton