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Variants in the fetal genome near FLT1 are associated with risk of preeclampsia

McGinnis R et al.

Nature Genetics, Volume:49,Pages:1255–1260, 2017

Editor's comment: Prof. Jim Thornton: Closing in on the “pre-eclampsia gene”

The InterPregGen group of researchers performed genome wide sequencing studies on 2,658 offspring from pre-eclamptic pregnancies and controls, using cohorts collected from UK, Iceland, Finland and Norway.  After testing over 7 million sequence variations they identified one, rs4769613, which was associated with the disease at the P = 3.2 x 10-8 significance level. Unlike previous purported associations this one is likely to be real. rs4769613 is located near the FLT1 locus.

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Commentaries by Editor Prof. Jim Thornton